TRASTUZUMAB PACKAGE INSERT - AN OVERVIEW

The phosphorylated HER3 presents docking websites for p85 subunit of PI3K. The completely activated PI3K intricate is produced by binding of p110 subunit of PI3K to p85 which can deliver PIP3 by using phosphorylating the PIP2. AKT binds to PIP3 and is phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both equally threonine and serin phos